Alterations of karyotype and oncogenicity in mouse myeloma MOPC-315 and 5-bromodeoxyuridine-resistant cell lines.
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Non-Invasive Imaging Provides Spatiotemporal Information on Disease Progression and Response to Therapy in a Murine Model of Multiple Myeloma
BACKGROUND Multiple myeloma (MM) is a B-cell malignancy, where malignant plasma cells clonally expand in the bone marrow of older people, causing significant morbidity and mortality. Typical clinical symptoms include increased serum calcium levels, renal insufficiency, anemia, and bone lesions. With standard therapies, MM remains incurable; therefore, the development of new drugs or immune cell...
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DNA-dependent RNA polymerase I was purified from the mouse myeloma, MOPC 315. The enzyme was solubilized from purified nucleoli and subjected to chromatography on CM-Sephadex, DEAE-Sephadex, and phosphocellulose ion exchange resins and to sedimentation in sucrose gradients. These procedures yielded a chromatographically homogeneous enzyme which was purified almost lO,OOO-fold with respect to wh...
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Antiidiotypic antibody (AIA) was raised in mice by immuni zation with MOPC 315 immunoglobulin A emulsified in Freund's adjuvant (FA). The antibody content of mouse serum was assessed by (a) its ability to inhibit resetting of 2,4,6-trinitrophenyl-sheep red blood cells around MOPC 315 myeloma cells, and (b) by a solid phase antigen-binding plate assay based on reactivity with 125l-Protein A and ...
متن کاملInduction of cytotoxic factors by immunization of mice with Freund's adjuvant components.
Antiidiotypic antibody (AIA) was raised in mice by immunization with MOPC 315 immunoglobulin A emulsified in Freund's adjuvant (FA). The antibody content of mouse serum was assessed by (a) its ability to inhibit rosetting of 2,4,6-trinitro-phenyl-sheep red blood cells around MOPC 315 myeloma cells, and (b) by a solid phase antigen-binding plate assay based on reactivity with 125I-Protein A and ...
متن کاملAntitumor activity and murine pharmacokinetics of parenteral acronycine.
The lipophilic antitumor alkaloid acronycine (ACRO) was solubilized in the cosolvent system used for etoposide. ACRO in this etoposide diluent (VPD) was found to be cytotoxic (less than or equal to 50% colony formation in soft agar) in fresh human tumors from patients with renal cell cancer, ovarian cancer, uterine cancer, and metastatic tumors of unknown primary. In P-glycoprotein-positive, mu...
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عنوان ژورنال:
- Cancer research
دوره 34 11 شماره
صفحات -
تاریخ انتشار 1974